| Product Name | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | RPB555Hu01-Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b Kappa |
| Host Species | Mouse |
| Tested Applications | Testing in progress |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A/G |
| Gene Symbol | ADAM17 |
|---|---|
| Gene Synonyms | CSVP,TACE,NISBD,ADAM18,CD156B,HYPT16,NISBD1 |
| Gene Full Name | ADAM metallopeptidase domain 17 |
| Gene Summary | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020] |
| Alternative Names | CD156b TACE CSVP Tumor Necrosis Factor Alpha Converting Enzyme Disintegrin and metalloproteinase domain-containing protein 17 Snake venom-like protease |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
