This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]
Alternative Names
ATP-dependent RNA helicase DDX5 ddx5 gene protein DEAD (Asp-Glu-Ala-Asp) box helicase 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5 DEAD box protein 5 DEAD box RNA helicase DEAD1 DEAD box-5 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase 68kD) DKFZp434E109 DKFZp686J01190 mDEAD1 MGC118083 p68 RNA helicase RNA helicase p68 RNA helicase transcription factor RP23-247J12.4