This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Alternative Names
brain-type cannabinoid receptor Cannabinoid CB1 receptor cannabinoid receptor 1 (brain) CB1 receptor central cannabinoid receptor HGNC:2159 N-terminal variant OTTHUMP00000016839 RP1-23D17.1 striatal cannabinoid receptor type 1 protein