This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
fox-1 homolog B fox-1 homolog Fxh fox-1 homologue Fyn-binding molecule 2 hexaribonucleotide-binding protein 2 RBFOX2 RBM9 RBM9 splice variant RTA repressor of tamoxifen transcriptional activity repressor of tamoxifen transcriptional activity RNA binding protein fox-1 homolog 2 RNA-binding motif protein 9 RNA-binding protein RNA-binding protein 9 RNA-binding protein FOX2