This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]
Alternative Names
anhidrotic ectodysplasin receptor 1 downless downless homolog downless mouse homolog of ectodermal dysplasia receptor ectodysplasin 1 anhidrotic receptor ectodysplasin A1 receptor EDA-A1 receptor Edar similar to TNF receptor hypohidrotic ectodermal dysplasia receptor for tumor necrosis factor superfamily member ectodysplasin A1 TNF receptor homolog