Rabbit polyclonal to COMPCOMP is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
Immunogen
Recombinant rat COMP (Type III repeats + C terminal region).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCIHC-PWB
WB: Use at a dilution of 1:1000. Predicted molecular weight: 84 kDa. Optimal dilutions/concentrations should be determined by the end user.:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
PSACH MGC131819 EDM1 132400 MED EPD1 COMP P49747
Target
COMP
Cellular Localization
Secreted
Application Notes
WB: Use at a dilution of 1:1000. Predicted molecular weight: 84 kDa. Optimal dilutions/concentrations should be determined by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.