Immunohistochemical
Sample Type: Mouse Brain Slices Red: primaryBlue: DAPIPrimary Dilution: 1:400 Secondary Antibody: Anti-Rabbit IgG Alexa 594Secondary Dilution: 1:400 Image Submitted By: Adahir Labrador-Garrido and Cintia Roodveldt University of SevilleWestern blot
0.2-1 ug/mlPositive Control: 721_B cell lysate| Product Name | Rabbit anti-FKBP4 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FKBP52, FKBP59, HBI, Hsp56, PPIase, p52, FKBP51 |
| Immunogen | The immunogen for anti-FKBP4 antibody: synthetic peptide directed towards the C terminal of human FKBP4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FKBP4 |
|---|---|
| Gene Synonyms | FKBP52 FKBP59 HBI Hsp56 PPIase p52 FKBP51 |
| Gene Full Name | FK506 binding protein 4, 59kDa |
| Gene Summary | FKBP4 is a component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S. It may have a rotamase activity. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Alternative Names | FKBP52 FKBP59 HBI Hsp56 PPIase p52 FKBP51 |
| Molecular Weight(MW) | 52kDa |
| Sequence | 459 amino acids |
Immunohistochemical
Sample Type: Mouse Brain Slices Red: primaryBlue: DAPIPrimary Dilution: 1:400 Secondary Antibody: Anti-Rabbit IgG Alexa 594Secondary Dilution: 1:400 Image Submitted By: Adahir Labrador-Garrido and Cintia Roodveldt University of Seville
Western blot
0.2-1 ug/mlPositive Control: 721_B cell lysate| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
