Western blot
Titration: 1.0 ug/ml| Product Name | Snf8 antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Species Reactivity | Bovine,Dog,Guinea Pig,Human,Mouse,Rat,Zebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Snf8 |
|---|---|
| Gene Synonyms | D11moh34 MGC105799 RGD1310144 |
| Gene Full Name | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) |
| Gene Summary | Snf8 is required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is a component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. |
| Alternative Names | D11moh34 MGC105799 RGD1310144 |
| Molecular Weight(MW) | 28kDa |
| Sequence | 258 amino acids |
| Entrez Gene | 287645 |
|---|---|
| SwissProt ID | Q5RK19 |
| Protein Accession | NP_001007805 |
Western blot
Titration: 1.0 ug/ml| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
