Immunohistochemistry
Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5ug/ml using anti-DBI antibodyWestern blot
0.2-1 ug/mlWB
(M) Western blot analysis of the efficacy of shRNA against mouse Dbi.| Product Name | DBI antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-DBI antibody: synthetic peptide directed towards the N terminal of human DBI |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | DBI |
|---|---|
| Gene Synonyms | ACBD1 ACBP CCK-RP EP MGC70414 |
| Gene Full Name | Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) |
| Gene Summary | DBI is diazepam binding inhibitor. The protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. DBI is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. |
| Alternative Names | ACBD1 ACBP CCK-RP EP MGC70414 |
| Molecular Weight(MW) | 10kDa |
| Sequence | 87 amino acids |
| Entrez Gene | 1622 |
|---|---|
| SwissProt ID | P07108 |
| Protein Accession | NP_001073331 |
Immunohistochemistry
Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5ug/ml using anti-DBI antibody
Western blot
0.2-1 ug/ml
WB
(M) Western blot analysis of the efficacy of shRNA against mouse Dbi.| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
