Immunohistochemistry
Immunohistochemistry with Pancreas tissue at an antibody concentration of 5ug/ml using anti-PCSK1 antibodyWestern blot
0.2-1 ug/ml| Product Name | PCSK1 antibody - middle region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-PCSK1 antibody: synthetic peptide directed towards the middle region of human PCSK1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB,IHC |
| Species Reactivity | Bovine,Dog,Horse,Human,Pig,Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PCSK1 |
|---|---|
| Gene Synonyms | NEC1 PC1 PC3 SPC3 BMIQ12 |
| Gene Full Name | Proprotein convertase subtilisin/kexin type 1 |
| Gene Summary | PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Alternative Names | NEC1 PC1 PC3 SPC3 BMIQ12 |
| Molecular Weight(MW) | 71kDa |
| Sequence | 753 amino acids |
Immunohistochemistry
Immunohistochemistry with Pancreas tissue at an antibody concentration of 5ug/ml using anti-PCSK1 antibody
Western blot
0.2-1 ug/ml| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
