Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate| Product Name | Rabbit anti-UMOD polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP |
| Immunogen | The immunogen for anti-UMOD antibody: synthetic peptide directed towards the C terminal of human UMOD |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | UMOD |
|---|---|
| Gene Synonyms | ADMCKD2 FJHN HNFJ HNFJ1 MCKD2 THGP THP |
| Gene Full Name | Uromodulin |
| Gene Summary | This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. |
| Alternative Names | ADMCKD2 FJHN HNFJ HNFJ1 MCKD2 THGP THP |
| Molecular Weight(MW) | 67kDa |
| Sequence | 640 amino acids |
| Entrez Gene | 7369 |
|---|---|
| SwissProt ID | P07911 |
| Protein Accession | NP_001008390 |
Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
