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NP antibody - middle region

Catalog Number:OM113284
OM113284
Discount Price
OM113284-100ul
1~2 Week
100ul
OM113284-50ul
50ul
OM113284-20ul
20ul
1~2 Week
Product Profile
Product Name NP antibody - middle region
Antibody Type Primary Antibodies
Immunogen The immunogen for anti-NP antibody: synthetic peptide directed towards the middle region of human NP
Key Feature
Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications WB
Species Reactivity Bovine,Dog,Guinea Pig,Human,Mouse,Pig,Rabbit,Rat,Zebra Fish
Concentration 1mg/ml
Purification Affinity purified
Target Information
Gene Symbol NP
Gene Synonyms MGC117396
MGC125915
MGC125916
PNP
PRO1837
PUNP
NP
Gene Full Name Purine nucleoside phosphorylase
Gene Summary Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. The specific function of NP is not yet known.This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alternative Names MGC117396
MGC125915
MGC125916
PNP
PRO1837
PUNP
NP
Molecular Weight(MW) 32kDa
Sequence 289 amino acids
Database Links
Entrez Gene 4860
SwissProt ID P00491
Protein Accession NP_000261
Application

Western blot

Host: Rabbit
Target Name: PNP
Sample Tissue: COLO205
Antibody Dilution: 1.0ug/ml

Western blot

Host: Rabbit
Target Name: PNP
Sample Tissue: HT1080
Antibody Dilution: 1.0ug/ml

Western blot

Host: Rabbit
Target Name: PNP
Sample Tissue: Human Fetal Liver
Antibody Dilution: 1.0ug/ml

Western blot

Host: Rabbit
Target Name: PNP
Sample Tissue: Human Adult Placenta
Antibody Dilution: 1.0ug/ml

Western blot

Host: Rabbit
Target Name: PNP
Sample Tissue: MCF7
Antibody Dilution: 1.0ug/ml

Western blot

0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: THP-1 cell lysate
Additional Information
Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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