Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Mouse Heart| Product Name | Rabbit anti-Fzr1 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AW108046, Cdh1, FZR, FZR2, Fyr, HCDH, HCDH1 |
| Immunogen | The immunogen for anti-Fzr1 antibody: synthetic peptide corresponding to a region of Mouse |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseMousePigRatZebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Fzr1 |
|---|---|
| Gene Synonyms | AW108046 Cdh1 FZR FZR2 Fyr HCDH HCDH1 |
| Gene Full Name | Fizzy/cell division cycle 20 related 1 (Drosophila) |
| Gene Summary | Fzr1 is the key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Fzr1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
| Alternative Names | AW108046 Cdh1 FZR FZR2 Fyr HCDH HCDH1 |
| Molecular Weight(MW) | 55kDa |
| Sequence | 493 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Mouse Heart| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
