Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: NCI-H226 cell lysate| Product Name | Rabbit anti-FAS polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 |
| Immunogen | The immunogen for anti-FAS antibody: synthetic peptide directed towards the N terminal of human FAS |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FAS |
|---|---|
| Gene Synonyms | ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6 |
| Gene Full Name | Fas (TNF receptor superfamily, member 6) |
| Gene Summary | FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
| Alternative Names | ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6 |
| Molecular Weight(MW) | 36kDa |
| Sequence | 335 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: NCI-H226 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Data sheet for OM117909