Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: COLO205 cell lysate| Product Name | Rabbit anti-GCH1 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B |
| Immunogen | The immunogen for anti-GCH1 antibody: synthetic peptide directed towards the C terminal of human GCH1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMousePigRabbitRatZebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GCH1 |
|---|---|
| Gene Synonyms | DYT14 DYT5 DYT5a GCH GTP-CH-1 GTPCH1 HPABH4B |
| Gene Full Name | GTP cyclohydrolase 1 |
| Gene Summary | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. |
| Alternative Names | DYT14 DYT5 DYT5a GCH GTP-CH-1 GTPCH1 HPABH4B |
| Molecular Weight(MW) | 28kDa |
| Sequence | 250 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: COLO205 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
