Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: THP-1 cell lysate| Product Name | Rabbit anti-CD22 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FLJ22814, MGC130020, SIGLEC-2, SIGLEC2 |
| Immunogen | The immunogen for anti-CD22 antibody: synthetic peptide directed towards the N terminal of human CD22 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CD22 |
|---|---|
| Gene Synonyms | FLJ22814 MGC130020 SIGLEC-2 SIGLEC2 |
| Gene Full Name | CD22 molecule |
| Gene Summary | CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins; one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
| Alternative Names | FLJ22814 MGC130020 SIGLEC-2 SIGLEC2 |
| Molecular Weight(MW) | 95kDa |
| Sequence | 847 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: THP-1 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
