Western blot
Host: Rabbit Target Name: Pkn2 Sample Tissue: Mouse Thymus lysates Antibody Dilution: 1.0ug/ml| Product Name | Rabbit anti-Pkn2 Antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7 |
| Immunogen | The immunogen for Anti-Pkn2 antibody is: synthetic peptide directed towards the C-terminal region of Mouse Pkn2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | MouseHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Pkn2 |
|---|---|
| Gene Synonyms | 6030436C20Rik AI507382 PRK2 Prkcl2 Stk7 |
| Gene Full Name | protein kinase N2 |
| Gene Summary | Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). |
| Alternative Names | 6030436C20Rik AI507382 PRK2 Prkcl2 Stk7 |
| Molecular Weight(MW) | 111kDa |
| Sequence | 983 amino acids |
Western blot
Host: Rabbit Target Name: Pkn2 Sample Tissue: Mouse Thymus lysates Antibody Dilution: 1.0ug/ml| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
