| Product Name | Rabbit anti-MYSM1 Antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 2A-DUB, 2ADUB, DKFZp779J1554, DKFZp779J1721, KIAA1915, RP4-592A1.1 |
| Immunogen | The immunogen for Anti-MYSM1 antibody is: synthetic peptide directed towards the C-terminal region of Human MYSM1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MYSM1 |
|---|---|
| Gene Synonyms | 2A-DUB 2ADUB DKFZp779J1554 DKFZp779J1721 KIAA1915 RP4-592A1.1 |
| Gene Summary | MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. |
| Alternative Names | 2A-DUB 2ADUB DKFZp779J1554 DKFZp779J1721 KIAA1915 RP4-592A1.1 |
| Molecular Weight(MW) | 91kDa |
| Sequence | 828 amino acids |
| Entrez Gene | 114803 |
|---|---|
| SwissProt ID | Q5VVJ2 |
| Protein Accession | NP_001078956 |
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
