Application
MAFB Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MAFB antibody detected the MAFB protein (arrow).Application
MAFB Antibody (C-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.| Product Name | MAFB Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBFC |
| WB:1:100~500 FC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KRML |
|---|---|
| Alternative Names | MAFB KRML Transcription factor MafB V-maf musculoaponeurotic fibrosarcoma oncogene homolog B |
| Molecular Weight(MW) | 35792 Da |
| Function | Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity) Involved either as an oncogene or as a tumor suppressor, depending on the cell context |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Nucleus (By similarity). |
| Entrez Gene | 9935 |
|---|---|
| Nucleotide Accession | NP_005452.2 |
Application
MAFB Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MAFB antibody detected the MAFB protein (arrow).
Application
MAFB Antibody (C-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 FC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
