Application
Western blot analysis of MLL3 Antibody (C-term) in HEK 293 cell line lysates. MLL3 (arrow) was detected using the purified Pab (1:1000 dilution).| Product Name | MLL3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MLL3; HALR; KIAA1506; KMT2C; Histone-lysine N-methyltransferase MLL3; Homologous to ALR protein; Lysine N-methyltransferase 2C; Myeloid/lymphoid or mixed-lineage leukemia protein 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | HALR KIAA1506 KMT2C |
|---|---|
| Alternative Names | MLL3 HALR KIAA1506 KMT2C Histone-lysine N-methyltransferase MLL3 Homologous to ALR protein Lysine N-methyltransferase 2C Myeloid/lymphoid or mixed-lineage leukemia protein 3 |
| Molecular Weight(MW) | 541370 Da |
| Function | Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder |
| Tissue Specificity | Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver |
| Cellular Localization | Nucleus (Probable). |
| Entrez Gene | 58508 |
|---|
Application
Western blot analysis of MLL3 Antibody (C-term) in HEK 293 cell line lysates. MLL3 (arrow) was detected using the purified Pab (1:1000 dilution).| Application Notes | WB:1:500~1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
