Application
mouse TSC1 Antibody (Center T515) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the mouse TSC1 antibody detected the mouse TSC1 protein (arrow).| Product Name | TSC1 Antibody (Center T515) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Kiaa0243 |
|---|---|
| Alternative Names | Tsc1 Kiaa0243 Hamartin Tuberous sclerosis 1 protein homolog |
| Molecular Weight(MW) | 128746 Da |
| Function | In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity) |
| Tissue Specificity | This mouse TSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-529 amino acids from the Central region of mouse TSC1. |
| Cellular Localization | Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=At steady state found in association with membranes (By similarity) |
| Entrez Gene | 64930 |
|---|---|
| Nucleotide Accession | NP_075025.2 |
Application
mouse TSC1 Antibody (Center T515) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the mouse TSC1 antibody detected the mouse TSC1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
