Application
Western blot analysis of BTBD14B Antibody (C-term) in mouse heart tissue lysates (35ug/lane). BTBD14B (arrow) was detected using the purified Pab (1:60 dilution).| Product Name | Nac1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NACC1; BTBD14B; NAC1; Nucleus accumbens-associated protein 1; BTB/POZ domain-containing protein 14B |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50:100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BTBD14B NAC1 |
|---|---|
| Alternative Names | NACC1 BTBD14B NAC1 Nucleus accumbens-associated protein 1 BTB/POZ domain-containing protein 14B |
| Molecular Weight(MW) | 57258 Da |
| Function | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines |
| Tissue Specificity | Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer |
| Cellular Localization | Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation (By similarity) |
| Entrez Gene | 112939 |
|---|
Application
Western blot analysis of BTBD14B Antibody (C-term) in mouse heart tissue lysates (35ug/lane). BTBD14B (arrow) was detected using the purified Pab (1:60 dilution).| Application Notes | WB:1:50:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
