Application
Western blot analysis on HeLa cell lysates using anti-Phospho-p130Cas (pY410) RabMAb (Cat. #AJ1564a). Cells were either (A) untreated (B) treated with pervanadate| Product Name | p130Cas Antibody Phospho (pY410) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification | p-Y410 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EPR1860 |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:2500~5000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CAS CASS1 CRKAS |
|---|---|
| Molecular Weight(MW) | 93372 Da |
| Function | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells |
| Tissue Specificity | Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line |
| Cellular Localization | Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation (By similarity) |
| Entrez Gene | 9564 |
|---|
Application
Western blot analysis on HeLa cell lysates using anti-Phospho-p130Cas (pY410) RabMAb (Cat. #AJ1564a). Cells were either (A) untreated (B) treated with pervanadate| Application Notes | WB:1:2500~5000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
