Application
A. Western blot analysis on (A, B) human brain tissue lysate and rat brain lysate (C, D) using anti-phospho PSD95 (pS295) RabMAb (Cat. #AJ1661b), 1:20,000 dilution. Cells were either (A, C) treated (B, D) untreated with LP| Product Name | PSD95 Antibody Phospho (pS295) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DLG4, PSD95, Disks large homolog 4, Synapse-associated protein 90 |
| Modification | p-S295 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP2615Y |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PSD95 |
|---|---|
| Alternative Names | DLG4 PSD95 Disks large homolog 4 Synapse-associated protein 90 |
| Molecular Weight(MW) | 80495 Da |
| Function | Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) |
| Tissue Specificity | Brain. |
| Cellular Localization | Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell junction, synapse, synaptosome (By similarity). Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells |
| Entrez Gene | 1742 |
|---|
Application
A. Western blot analysis on (A, B) human brain tissue lysate and rat brain lysate (C, D) using anti-phospho PSD95 (pS295) RabMAb (Cat. #AJ1661b), 1:20,000 dilution. Cells were either (A, C) treated (B, D) untreated with LP| Application Notes | WB:1:2000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
