Application
A. Western blot analysis on fetal brain lysate using anti-RanBP9 RabMAb (Cat. #AJ1675a), dilution 1:1000.Application
B. Immunohistochemical staining of paraffin-embedded human lymphoma using anti-RanBP9 RabMAb (Cat. #AJ1675a).| Product Name | RanBP9 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IPO9, IMP9, KIAA1192, RANBP9, Importin-9, Ran-binding protein 9 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1353Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100000~200000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IMP9 KIAA1192 RANBP9 |
|---|---|
| Alternative Names | IPO9 IMP9 KIAA1192 RANBP9 Importin-9 Ran-binding protein 9 |
| Molecular Weight(MW) | 115963 Da |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6 |
| Tissue Specificity | A synthetic peptide corresponding to residues on the C-terminus of human RANBP9 was used as an immunogen. |
| Cellular Localization | Cytoplasm (By similarity). Nucleus (By similarity) |
| Entrez Gene | 55705 |
|---|
Application
A. Western blot analysis on fetal brain lysate using anti-RanBP9 RabMAb (Cat. #AJ1675a), dilution 1:1000.
Application
B. Immunohistochemical staining of paraffin-embedded human lymphoma using anti-RanBP9 RabMAb (Cat. #AJ1675a).| Application Notes | WB:1:100000~200000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
