Application
TRIP10 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TRIP10 antibody detected the TRIP10 protein (arrow).| Product Name | TRIP10 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRIP10; CIP4; STOT; STP; Cdc42-interacting protein 4; Protein Felic; Salt tolerant protein; Thyroid receptor-interacting protein 10 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CIP4 STOT STP |
|---|---|
| Alternative Names | TRIP10 CIP4 STOT STP Cdc42-interacting protein 4 Protein Felic Salt tolerant protein Thyroid receptor-interacting protein 10 |
| Molecular Weight(MW) | 68352 Da |
| Function | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity) Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells May be required for the lysosomal retention of FASLG/FASL |
| Tissue Specificity | Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea |
| Cellular Localization | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F- actin, to lysosomes and to sites of phagocytosis in macrophages Also localizes to the Golgi, and this requires AKAP9 |
| Entrez Gene | 9322 |
|---|---|
| Nucleotide Accession | NP_004231.1 |
Application
TRIP10 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TRIP10 antibody detected the TRIP10 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
