Application
TRPM2 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the TRPM2 antibody detected the TRPM2 protein (arrow).Application
VN1R1 Antibody (N-term) (AP14200b)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of VN1R1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | TRPM2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRPM2; EREG1; KNP3; LTRPC2; TRPC7; Transient receptor potential cation channel subfamily M member 2; Estrogen-responsive element-associated gene 1 protein; Long transient receptor potential channel 2; Transient receptor potential channel 7 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | EREG1 KNP3 LTRPC2 TRPC7 |
|---|---|
| Alternative Names | TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Transient receptor potential cation channel subfamily M member 2 Estrogen-responsive element-associated gene 1 protein Long transient receptor potential channel 2 Transient receptor potential channel 7 |
| Molecular Weight(MW) | 171198 Da |
| Function | Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity |
| Tissue Specificity | Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Entrez Gene | 7226 |
|---|---|
| Nucleotide Accession | NP_003298.1 |
Application
TRPM2 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the TRPM2 antibody detected the TRPM2 protein (arrow).
Application
VN1R1 Antibody (N-term) (AP14200b)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of VN1R1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
