Application
UHRF2 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the UHRF2 antibody detected the UHRF2 protein (arrow).| Product Name | UHRF2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | UHRF2; NIRF; RNF107; E3 ubiquitin-protein ligase UHRF2; Np95/ICBP90-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-cont |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NIRF RNF107 |
|---|---|
| Alternative Names | UHRF2 NIRF RNF107 E3 ubiquitin-protein ligase UHRF2 Np95/ICBP90-like RING finger protein Nuclear protein 97 Nuclear zinc finger protein Np97 RING finger protein 107 Ubiquitin-like PHD and RING finger domain-containing protein 2 Ubiquitin-like-cont |
| Molecular Weight(MW) | 89985 Da |
| Function | E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Appears to contribute to tumorigenesis |
| Tissue Specificity | This UHRF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 478-508 amino acids from the Central region of human UHRF2. |
| Cellular Localization | Nucleus. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity) |
| Entrez Gene | 115426 |
|---|---|
| Nucleotide Accession | NP_690856.1 |
Application
UHRF2 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the UHRF2 antibody detected the UHRF2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
