Application
Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center N153) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR1 gene (Lane 2) (Origene Technologies).Application
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.Application
ACVR1 Antibody western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ACVR1 antibody detected the ACVR1 protein (arrow).| Product Name | Activin Receptor Type IA (ACVR1) Antibody (Center N153) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ACVR1; ACVRLK2; Activin receptor type-1; Activin receptor type I; Activin receptor-like kinase 2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:50~200 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ACVRLK2 |
|---|---|
| Alternative Names | ACVR1 ACVRLK2 Activin receptor type-1 Activin receptor type I Activin receptor-like kinase 2 Serine/threonine-protein kinase receptor R1 TGF-B superfamily receptor type I |
| Molecular Weight(MW) | 57153 Da |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity) |
| Tissue Specificity | Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 90 |
|---|
Application
Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center N153) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR1 gene (Lane 2) (Origene Technologies).
Application
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Application
ACVR1 Antibody western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ACVR1 antibody detected the ACVR1 protein (arrow).| Application Notes | WB:1:50~200 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
