Application
Western blot analysis of APS-pY629（) in HL60 cell line lysates (35ug/lane) APS (arrow) was detected using the purified Pab.| Product Name | APS Antibody (Y629) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SH2B2; APS; SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50~100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | APS |
|---|---|
| Alternative Names | SH2B2 APS SH2B adapter protein 2 Adapter protein with pleckstrin homology and Src homology 2 domains SH2 and PH domain-containing adapter protein APS |
| Molecular Weight(MW) | 67738 Da |
| Function | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways May be involved in coupling from immunoreceptor to Ras signaling Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 |
| Tissue Specificity | Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines |
| Cellular Localization | Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region |
| Entrez Gene | 10603 |
|---|
Application
Western blot analysis of APS-pY629（) in HL60 cell line lysates (35ug/lane) APS (arrow) was detected using the purified Pab.| Application Notes | WB:1:50~100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
