Application
BRD7 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the BRD7 antibody detected the BRD7 protein (arrow).| Product Name | BRD7 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BRD7; BP75; CELTIX1; Bromodomain-containing protein 7; 75 kDa bromodomain protein; Protein CELTIX-1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BP75 CELTIX1 |
|---|---|
| Alternative Names | BRD7 BP75 CELTIX1 Bromodomain-containing protein 7 75 kDa bromodomain protein Protein CELTIX-1 |
| Molecular Weight(MW) | 74139 Da |
| Function | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase |
| Tissue Specificity | This BRD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-107 amino acids from the N-terminal region of human BRD7. |
| Cellular Localization | Isoform 2: Nucleus. |
| Entrez Gene | 29117 |
|---|---|
| Nucleotide Accession | NP_001167455.1 NP_037395.2 |
Application
BRD7 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the BRD7 antibody detected the BRD7 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
