Application
A. Immunohistochemical staining of paraffin-embedded human tonsil stained with anti-CD79a RabMAb (Cat. #AJ1169a)| Product Name | CD79a/IGBP1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD79A, IGA, MB1, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha;MB-1 membrane glycoprotein;Surface IgM-associated protein;Membrane-bound immunoglobulin-associated protein |
| Clonality | Monoclonal |
|---|---|
| Clone Number | SP18 |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:100~1:300 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IGA MB1 |
|---|---|
| Alternative Names | CD79A IGA MB1 B-cell antigen receptor complex-associated protein alpha chain Ig-alpha MB-1 membrane glycoprotein Surface IgM-associated protein Membrane-bound immunoglobulin-associated protein |
| Molecular Weight(MW) | 25038 Da |
| Function | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells |
| Tissue Specificity | B-cells. |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity) |
| Entrez Gene | 973 |
|---|
Application
A. Immunohistochemical staining of paraffin-embedded human tonsil stained with anti-CD79a RabMAb (Cat. #AJ1169a)| Application Notes | IHC:1:100~1:300 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
