Application
Western blot analysis of CORIN Antibody (Center) in mouse heart tissue lysates (35ug/lane). CORIN (arrow) was detected using the purified Pab.| Product Name | CORIN Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CORIN; CRN; TMPRSS10; Atrial natriuretic peptide-converting enzyme; Corin; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme; Transmembrane protease serine 10; Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natr |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CRN TMPRSS10 |
|---|---|
| Alternative Names | CORIN CRN TMPRSS10 Atrial natriuretic peptide-converting enzyme Corin Heart-specific serine proteinase ATC2 Pro-ANP-converting enzyme Transmembrane protease serine 10 Atrial natriuretic peptide-converting enzyme N-terminal propeptide Atrial natr |
| Molecular Weight(MW) | 116486 Da |
| Function | Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide |
| Tissue Specificity | Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level) |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. Note=May easily detached from the endothelial cell membrane Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10 Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage |
| Entrez Gene | 10699 |
|---|
Application
Western blot analysis of CORIN Antibody (Center) in mouse heart tissue lysates (35ug/lane). CORIN (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Data sheet for OM230206