Application
Western blot analysis of anti-CTDSP2 Pab in CEM cell line tissue lysate (35ug/lane).CTDSP2(arrow) was detected using the purified Pab (1:60 dilution).Application
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.| Product Name | CTDSP2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CTDSP2; NIF2; OS4; SCP2; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; Nuclear LIM interactor-interacting factor 2; Protein OS-4; Small C-terminal domain phosphatase 2; Small CTD phosphatase 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NIF2 OS4 SCP2 |
|---|---|
| Alternative Names | CTDSP2 NIF2 OS4 SCP2 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Nuclear LIM interactor-interacting factor 2 Protein OS-4 Small C-terminal domain phosphatase 2 Small CTD phosphatase 2 |
| Molecular Weight(MW) | 30664 Da |
| Function | Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas |
| Tissue Specificity | Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver |
| Cellular Localization | Nucleus (By similarity). |
Application
Western blot analysis of anti-CTDSP2 Pab in CEM cell line tissue lysate (35ug/lane).CTDSP2(arrow) was detected using the purified Pab (1:60 dilution).
Application
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
