Application
CUGBP2 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CUGBP2 antibody detected the CUGBP2 protein (arrow).| Product Name | CUGBP2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CELF2; BRUNOL3; CUGBP2; ETR3; NAPOR; CUGBP Elav-like family member 2; Bruno-like protein 3; CUG triplet repeat RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; ELAV-type RNA-binding protein 3; Neuroblastoma apoptosis-related RNA-binding protein; RNA |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BRUNOL3 CUGBP2 ETR3 NAPOR |
|---|---|
| Alternative Names | CELF2 BRUNOL3 CUGBP2 ETR3 NAPOR CUGBP Elav-like family member 2 Bruno-like protein 3 CUG triplet repeat RNA-binding protein 2 CUG-BP- and ETR-3-like factor 2 ELAV-type RNA-binding protein 3 Neuroblastoma apoptosis-related RNA-binding protein RNA |
| Molecular Weight(MW) | 54285 Da |
| Function | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre- mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity) |
| Tissue Specificity | Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas |
| Cellular Localization | Nucleus. Cytoplasm. Note=Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments |
| Entrez Gene | 10659 |
|---|---|
| Nucleotide Accession | NP_001020247.1 NP_001020248.1 |
Application
CUGBP2 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CUGBP2 antibody detected the CUGBP2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
