Application
DACH1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the DACH1 antibody detected the DACH1 protein (arrow).| Product Name | DACH1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DACH1; DACH; Dachshund homolog 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DACH |
|---|---|
| Alternative Names | DACH1 DACH Dachshund homolog 1 |
| Molecular Weight(MW) | 78562 Da |
| Function | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity) |
| Tissue Specificity | Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen |
| Cellular Localization | Nucleus. |
| Entrez Gene | 1602 |
|---|---|
| Nucleotide Accession | NP_542938.2 NP_542937.2 |
Application
DACH1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the DACH1 antibody detected the DACH1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
