Application
Western blot analysis of anti-DHCR24 Antibody (Center) in HepG2 cell line lysates (35ug/lane). DHCR24 (arrow) was detected using the purified Pab.| Product Name | DHCR24 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DHCR24; KIAA0018; Delta(24)-sterol reductase; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50~100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0018 |
|---|---|
| Alternative Names | DHCR24 KIAA0018 Delta(24)-sterol reductase 24-dehydrocholesterol reductase 3-beta-hydroxysterol delta-24-reductase Diminuto/dwarf1 homolog Seladin-1 |
| Molecular Weight(MW) | 60101 Da |
| Function | Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis |
| Tissue Specificity | Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein |
| Entrez Gene | 1718 |
|---|
Application
Western blot analysis of anti-DHCR24 Antibody (Center) in HepG2 cell line lysates (35ug/lane). DHCR24 (arrow) was detected using the purified Pab.| Application Notes | WB:1:50~100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
