Application
A. Western blot analysis on HeLa cell lysate using anti-DLC8 RabMAb (Cat. #AJ1241a), dilution 1:10,000.Application
B. Immunohistochemical staining of paraffin-embedded human liver using anti-DLC8 RabMAb (Cat. #AJ1241a).| Product Name | DLC8 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DYNLL1, DLC1, DNCL1, DNCLC1, HDLC1, Dynein light chain 1, cytoplasmic, Dynein light chain LC8-type 1;8 kDa dynein light chain;DLC8;Protein inhibitor of neuronal nitric oxide synthase |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1660Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:2000~5000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DLC1 DNCL1 DNCLC1 HDLC1 |
|---|---|
| Alternative Names | DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 Dynein light chain 1 cytoplasmic Dynein light chain LC8-type 1 8 kDa dynein light chain DLC8 Protein inhibitor of neuronal nitric oxide synthase |
| Molecular Weight(MW) | 10366 Da |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria |
| Entrez Gene | 8655 |
|---|
Application
A. Western blot analysis on HeLa cell lysate using anti-DLC8 RabMAb (Cat. #AJ1241a), dilution 1:10,000.
Application
B. Immunohistochemical staining of paraffin-embedded human liver using anti-DLC8 RabMAb (Cat. #AJ1241a).| Application Notes | WB:1:2000~5000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
