Application
ENPP1 Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the ENPP1 antibody detected the ENPP1 protein (arrow).| Product Name | ENPP1 (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ENPP1; M6S1; NPPS; PC1; PDNP1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; Membrane component chromosome 6 surface marker 1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1; Alkaline phosphodie |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | M6S1 NPPS PC1 PDNP1 |
|---|---|
| Alternative Names | ENPP1 M6S1 NPPS PC1 PDNP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Membrane component chromosome 6 surface marker 1 Phosphodiesterase I/nucleotide pyrophosphatase 1 Plasma-cell membrane glycoprotein PC-1 Alkaline phosphodie |
| Molecular Weight(MW) | 104924 Da |
| Function | Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity |
| Tissue Specificity | Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis |
| Cellular Localization | Membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side |
| Entrez Gene | 5167 |
|---|---|
| Nucleotide Accession | NP_006199.2 |
Application
ENPP1 Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the ENPP1 antibody detected the ENPP1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
