Application
Western blot analysis of FAM175A Antibody (Center) in 293 cell line lysates (35ug/lane). FAM175A (arrow) was detected using the purified Pab.| Product Name | FAM175A Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FAM175A; ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; Coiled-coil domain-containing protein 98; Protein FAM175A |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ABRA1 CCDC98 |
|---|---|
| Alternative Names | FAM175A ABRA1 CCDC98 BRCA1-A complex subunit Abraxas Coiled-coil domain-containing protein 98 Protein FAM175A |
| Molecular Weight(MW) | 46663 Da |
| Function | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1 |
| Tissue Specificity | This FAM175A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237~267 amino acids from the Central region of human FAM175A . |
| Cellular Localization | Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) |
| Entrez Gene | 84142 |
|---|
Application
Western blot analysis of FAM175A Antibody (Center) in 293 cell line lysates (35ug/lane). FAM175A (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
