Application
FBXL10b (N-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the FBXL10b antibody detected the FBXL10b protein (arrow).Application
FBXL10b Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervical tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FBXL10b Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | FBXL10b Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2; Lysine-specific demethylase 2B; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CXXC2 FBL10 FBXL10 JHDM1B PCCX2 |
|---|---|
| Alternative Names | KDM2B CXXC2 FBL10 FBXL10 JHDM1B PCCX2 Lysine-specific demethylase 2B CXXC-type zinc finger protein 2 F-box and leucine-rich repeat protein 10 F-box protein FBL10 F-box/LRR-repeat protein 10 JmjC domain-containing histone demethylation protein 1B |
| Molecular Weight(MW) | 152615 Da |
| Function | Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex |
| Tissue Specificity | This FBXL10b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FBXL10b. |
| Cellular Localization | Nucleus, nucleolus. |
| Entrez Gene | 84678 |
|---|---|
| Nucleotide Accession | A8MRS1 NP_001005366 |
Application
FBXL10b (N-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the FBXL10b antibody detected the FBXL10b protein (arrow).
Application
FBXL10b Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervical tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FBXL10b Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
