Application
A. Western blot analysis on rat brain lysates using anti-Phospho-GluR1 (pS845) RabMAb (Cat. #AJ1322b), 1:20,000 dilution. Cells were either (A) untreated (B) treated with Lambda Phosphatase| Product Name | GluR1 Antibody Phospho (pS845) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GRIA1, GLUH1, GLUR1, Glutamate receptor 1, GluR-A;GluR-K1;Glutamate receptor ionotropic, AMPA 1;AMPA-selective glutamate receptor 1 |
| Modification | p-S845 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EPR2148 |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:1000~10000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | GLUH1 GLUR1 |
|---|---|
| Alternative Names | GRIA1 GLUH1 GLUR1 Glutamate receptor 1 GluR-A GluR-K1 Glutamate receptor ionotropic AMPA 1 AMPA-selective glutamate receptor 1 |
| Molecular Weight(MW) | 101506 Da |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate |
| Tissue Specificity | Widely expressed in brain. |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity) |
| Entrez Gene | 2890 |
|---|
Application
A. Western blot analysis on rat brain lysates using anti-Phospho-GluR1 (pS845) RabMAb (Cat. #AJ1322b), 1:20,000 dilution. Cells were either (A) untreated (B) treated with Lambda Phosphatase| Application Notes | WB:1:1000~10000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
