Application
GPM6A Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the GPM6A antibody detected the GPM6A protein (arrow).Application
GPM6A Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GPM6A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | GPM6A Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GPM6A; M6A; Neuronal membrane glycoprotein M6-a |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | M6A |
|---|---|
| Alternative Names | GPM6A M6A Neuronal membrane glycoprotein M6-a |
| Molecular Weight(MW) | 31210 Da |
| Function | Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor |
| Tissue Specificity | This GPM6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-278 amino acids from the C-terminal region of human GPM6A. |
| Cellular Localization | Cell membrane; Multi-pass membrane protein (By similarity). Cell projection, axon (By similarity). Cell projection, dendritic spine (By similarity). Cell projection, filopodium (By similarity). Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity) |
| Entrez Gene | 2823 |
|---|---|
| Nucleotide Accession | NP_005268.1 NP_963886.1 |
Application
GPM6A Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the GPM6A antibody detected the GPM6A protein (arrow).
Application
GPM6A Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GPM6A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
