Application
GPR120 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the GPR120 antibody detected the GPR120 protein (arrow).| Product Name | GPR120 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | O3FAR1; GPR120; GPR129; PGR4; Omega-3 fatty acid receptor 1; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | GPR120 GPR129 O3FAR1 PGR4 |
|---|---|
| Alternative Names | O3FAR1 GPR120 GPR129 PGR4 Omega-3 fatty acid receptor 1 G-protein coupled receptor 120 G-protein coupled receptor 129 G-protein coupled receptor GT01 G-protein coupled receptor PGR4 |
| Molecular Weight(MW) | 42241 Da |
| Function | Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation |
| Tissue Specificity | Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas |
| Cellular Localization | Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalized with ARRB2 following DHA treatment (By similarity) |
| Entrez Gene | 338557 |
|---|---|
| Nucleotide Accession | NP_859529.2 |
Application
GPR120 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the GPR120 antibody detected the GPR120 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
