Application
GPS1 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the GPS1 antibody detected the GPS1 protein (arrow).| Product Name | GPS1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GPS1; COPS1; CSN1; COP9 signalosome complex subunit 1; G protein pathway suppressor 1; JAB1-containing signalosome subunit 1; Protein MFH |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | COPS1 CSN1 |
|---|---|
| Alternative Names | GPS1 COPS1 CSN1 COP9 signalosome complex subunit 1 G protein pathway suppressor 1 JAB1-containing signalosome subunit 1 Protein MFH |
| Molecular Weight(MW) | 55537 Da |
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction |
| Tissue Specificity | Widely expressed. |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 2873 |
|---|---|
| Nucleotide Accession | NP_004118.3 NP_997657.1 |
Application
GPS1 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the GPS1 antibody detected the GPS1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
