Application
Western blot analysis of JMJD5 (arrow) using rabbit polyclonal JMJD5 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the JMJD5 gene (Lane 2).| Product Name | JMJD5 Antibody (C-term 2) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KDM8; JMJD5; Lysine-specific demethylase 8; JmjC domain-containing protein 5; Jumonji domain-containing protein 5 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50~100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | JMJD5 |
|---|---|
| Alternative Names | KDM8 JMJD5 Lysine-specific demethylase 8 JmjC domain-containing protein 5 Jumonji domain-containing protein 5 |
| Molecular Weight(MW) | 47270 Da |
| Function | Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation |
| Tissue Specificity | Weakly expressed in most cells. Highly expressed in breast cancer cells |
| Cellular Localization | Nucleus. |
| Entrez Gene | 79831 |
|---|
Application
Western blot analysis of JMJD5 (arrow) using rabbit polyclonal JMJD5 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the JMJD5 gene (Lane 2).| Application Notes | WB:1:50~100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
