Application
KLF1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the KLF1 antibody detected the KLF1 protein (arrow).| Product Name | KLF1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KLF1; EKLF; Krueppel-like factor 1; Erythroid krueppel-like transcription factor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | EKLF |
|---|---|
| Alternative Names | KLF1 EKLF Krueppel-like factor 1 Erythroid krueppel-like transcription factor |
| Molecular Weight(MW) | 38221 Da |
| Function | Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity) |
| Tissue Specificity | Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines |
| Cellular Localization | Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles (By similarity) |
| Entrez Gene | 10661 |
|---|---|
| Nucleotide Accession | NP_006554.1 |
Application
KLF1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the KLF1 antibody detected the KLF1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
