Application
Western blot analysis of anti-hLLGL1 Pab in 293 cell line lysate. hLLGL1(arrow) was detected using the purified Pab.| Product Name | LLGL1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LLGL1; DLG4; HUGL; HUGL1; Lethal(2) giant larvae protein homolog 1; Hugl-1; Human homolog to the D-lgl gene protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DLG4 HUGL HUGL1 |
|---|---|
| Alternative Names | LLGL1 DLG4 HUGL HUGL1 Lethal(2) giant larvae protein homolog 1 Hugl-1 Human homolog to the D-lgl gene protein |
| Molecular Weight(MW) | 115418 Da |
| Function | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane |
| Tissue Specificity | Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease |
| Cellular Localization | Early endosome membrane (By similarity). Golgi apparatus, trans-Golgi network membrane (By similarity) Golgi apparatus membrane (By similarity). Cell projection, axon (By similarity). Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developping axons (By similarity) |
| Entrez Gene | 3996 |
|---|
Application
Western blot analysis of anti-hLLGL1 Pab in 293 cell line lysate. hLLGL1(arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
