Rabbit polyclonal antibody to alpha 1b Adrenergic Receptor (adrenergic, alpha-1B-, receptor)Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq]
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human alpha 1b Adrenergic Receptor. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
*Optimal dilutions/concentrations should be determined by the researcher.
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Species Reactivity
Mouse
Predicted Reactivity
Human, Rat, Dog, Rabbit, BovineHuman (100%), Rat (100%), Dog (100%), Rabbit (100%), Bovine (100%)
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)