Application
Immunofluorescence of AXIN2 in Rat Lung cells with AXIN2 antibody at 20 ug/mL.Application
Immunohistochemistry of AXIN2 in rat lung tissue with AXIN2 antibody at 5 ug/mL.Application
Western blot analysis of AXIN2 in mouse lung lysate with AXIN2 antibody at 1 ug/mL.| Product Name | Axin 2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Axin 2The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
| Immunogen | AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-PWB |
| WB: 1 ug/ml. IHC-P: 5 ug/ml. IF: 20 ug/ml: |
|
| Species Reactivity | MouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | AXIN2 ODCRCS axin 2 AXIL |
|---|---|
| Target | Axin 2 |
| Tissue Specificity | AXIN2 antibody is predicted to not cross-react with AXIN1. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four. |
Application
Immunofluorescence of AXIN2 in Rat Lung cells with AXIN2 antibody at 20 ug/mL.
Application
Immunohistochemistry of AXIN2 in rat lung tissue with AXIN2 antibody at 5 ug/mL.
Application
Western blot analysis of AXIN2 in mouse lung lysate with AXIN2 antibody at 1 ug/mL.| Application Notes | WB: 1 ug/ml. IHC-P: 5 ug/ml. IF: 20 ug/ml: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Be stored at 4oC for three months and -20oC, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | PBS containing 0.02% sodium azide. |
